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ANOLET

 
 
 
   
   
   
 
 


 
   
 
             
     
     
    Composition
   
    Each Tablet of Anolet contains:
    Letrozole …...........2.5mg
   
   
    Indication & Dosage Oral:
   
 
  Endometriosis & Advanced or locally advanced breast cancer, Adjutant therapy   for postmenopausal women with hormone receptor positive early breast cancer
   
    Adult: 2.5 mg once daily.
   
   
    Hepatic impairment:
   
    Reduce dose by 50% in patients with cirrhosis and severe hepatic impairment;   recommended dose: 2.5 mg on alternate days.
   
   
    Special Populations:
   
    In renal failure: No dosage adjustment is required in patients with CrCl of at least 10   mL /min. In hepatic failure: No dosage adjustment is required in patients with mild   to moderate hepatic impairment. Use with caution.
  Administration May be taken with or without food.
   
   
    Contraindications:
   
 
  Premenopausal women and children; hypersensitivity.
   
   
    Special Precautions:
   
    Severe renal impairment; severe hepatic impairment; osteoporosis. Caution when   driving or operating machinery.
   
   
    Adverse Drug Reactions:
   
    Hot flushes, arthralgia, nausea, vomiting, fatigue, dizziness, headache, dyspepsia,   constipation, diarrhoea, anorexia, alopoecia, increased sweating, rash, peripheral   oedema, osteoporosis, musculoskeletal pain, vaginal irritation.
   
   
    Drug Interactions :
   
    Plasma levels reduced by tamoxifen.
   
   
    Presentations :
   
    A Blister Strip of 5 Tablets
   
 
 
 
   
 
         
 
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