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( Name changed from earlier Provogil to Pure HCG )

  Each ampoule of freeze dried Pure HCG 1000 / 2000 / 5000 / 10000 contains:
  Human Chorionic Gonadotrophin.....1000 / 2000 / 5000 / 10000 IU
Mannitol.....12 mg
Potassium Dihydrogen Orthophosphate.....0.46 mg
Dipotassium Hydrogen Orthophosphate.....0.36 mg
Reconstitute with 1ml of sodium chloride Injection (0.9%w/v) IP provided in the pack
  Therapeutic Indications & Usage
  Pure HCG is indicated for induction of ovulation and pregnancy in the anovulatory, infertile women in whom the cause of anovulation is secondary and not due to primary ovarian failure, & who has been appropriately pretreated with human menotropins. It is also indicated for selected cases of hypogonadotropic hypogonadism (hypogonadism secondary to pituitary failure) in males, as well as for prepubertal (between four and nine years of age) cryptorchidism not due to anatomical obstruction.
  Pure HCG is contraindicated in precocious puberty, prostatic carcinoma or other androgen dependent neoplasm, those hypersensitive to human chorionic gonadotropin (HCG) and during pregnancy.
  Since fluid retention can occur with HCG, Pure HCG must be given with caution in cardiac or renal disease, migraine, epilepsy and asthma.
  Induction of androgen secretion by HCG (Pure HCG) may induce precious puberty in those treated for cryptorchidism. Multiple births can result due to HCG (Pure HCG) treatment. Safety and efficacy of HCG (Pure HCG) during lactation and in children have not been established.
  Adverse Reactions
  HCG (Pure HCG) can cause headache, irritability, restlessness, depression, fatigue, edema, precocious puberty, gynecomastia, hypersensitivity reaction and pain at site of injection.
  The principal serious adverse reactions to HCG (Pure HCG) include ovarian hyperstimulation, rupture of ovarian cysts with resultant hemoperitoneum and arterial thromboembolism.
  Recommended Dosage & Administration
  Induction of Ovulation and Pregnancy: 1 Pure HCG 5000 / Pure HCG 10000 ampoule intramuscular (IM) one day following the last dose of menotropins.
  Hypogonadotropic Hypogonadism in Males: ½-1 Pure HCG 1000 ampoule IM three times a week for 3 weeks followed by the same dose IM twice a week for 3 weeks. Alternatively, 2 Pure HCG 2000 ampoules IM three times a week for 6-9 months, following the dose can be reduced to 1 Pure HCG 2000 ampoule IM three times weekly for an additional 3 months.
  Prepubertal Cryptorchidism:
  • 2 Pure HCG 2000 ampoules IM three times a week for 3 weeks; or
  • 1 Pure HCG 5000 ampoule IM alternate day for 4 injections; or
  • ½-1 Pure HCG 1000 ampoule IM for 15 such injections over a period of 6 weeks; or
  • ½ Pure HCG 1000 ampoule IM three times a week for 4-6 weeks; if not successful, another similar course is begun one month later giving 1 Pure HCG 1000 ampoule IM.
  Pure HCG/ Pure HCG HP 2000 Injections: 2000 IU ampoules.
Pure HCG/ Pure HCG HP 5000 Injections: 5000 IU ampoules.
Pure HCG/ Pure HCG HP 10000 Injections: 10000 IU ampoules.
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