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        Each tablet of DUOFLAM N contains:
        Diclofenac Potassium … 50 mg
Paracetamol … 500 mg
        Therapeutic Indications & Usage
        DUOFLAM N is indicated for mild to moderate pain associated with inflammation.
        DUOFLAM N is not advocated for those allergic to its ingredients, history of hypersensitivity to aspirin or other NSAIDs, aspirin-induced nasal polyps or bronchospasm, active peptic ulceration and in severe renal dysfunction.
        Known hypersensitivity to diclofenac or any ingredient in the formulations.
        History of asthma, urticaria, or other sensitivity reaction precipitated by aspirin or other NSAIDs.
        Treatment of perioperative pain in the setting of CABG surgery
        Precautions & Warnings
        DUOFLAM N is to be advocated with caution in liver & kidney damage, elderly, patients requiring surgery, anemia, bronchial asthma, stomatitis, compromised cardiac function, heart failure, pre-existing edema, systemic lupus erythematosus.
        Safe use of DUOFLAM N in pregnancy and lactation has not been established. DUOFLAM N should not be preferably coadministered with other NSAIDs, corticosteroids, hypoglycemics, digoxin, lithium, methotrexate, cyclosporine, coagulants & anticoagulants, bone marrow suppressants as well as probenecid.
        Adverse Reactions
        Side effects of paracetamol (in DUOFLAM) are rare, and usually mild. Skin rashes and other hypersensitivity reactions could occur, and, on rare occasions, paracetamol could cause hematological changes. Drug Interaction
        Absorption of paracetamol from DUOFLAM N is increased by concomitant metoclopramide, and such other agents. Probenecid can decrease it clearance and thereby increase paracetamol's plasma half-life when given along with DUOFLAM N
        Consider potential benefits and risks of diclofenac therapy as well as alternative therapies before initiating therapy with the drug. Use lowest effective dosage and shortest duration of therapy consistent with the patient’s treatment goals.
        Cardiovascular Effects
        Selective COX-2 inhibitors have been associated with increased risk of cardiovascular events (e.g., MI, stroke) in certain situations. Several prototypical NSAIDs also have been associated with increased risk of cardiovascular events. Current evidence suggests that use of diclofenac is associated with increased cardiovascular risk.
        GI Effects
        Serious GI toxicity (e.g., bleeding, ulceration, perforation) can occur with or without warning symptoms; increased risk in those with a history of GI bleeding or ulceration, geriatric patients, smokers, those with alcohol dependence, and those in poor general health.
        For patients at high risk for complications from NSAIA-induced GI ulceration (e.g., bleeding, perforation), consider concomitant use of misoprostol; alternatively, consider concomitant use of a proton-pump inhibitor (e.g., omeprazole) or use of an NSAIA that is a selective inhibitor of COX-2 (e.g., celecoxib).
        Renal Effects
        Direct renal injury, including renal papillary necrosis, reported in patients receiving long-term NSAIA therapy.
        Potential for overt renal decompensation. Increased risk of renal toxicity in patients with renal or hepatic impairment or heart failure, in geriatric patients, in patients with volume depletion, and in those receiving a diuretic, ACE inhibitor, or angiotensin II receptor antagonist
        Recommended Dosage & Administration
        DUOFLAM N Tab Bid/Tid, or as prescribed.
        As directed by Physician
        DUOFLAM N Tablets: Blisters of 15s


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