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        Each enteric coated tablet of DUOFLAM SP contains:
        Diclofenac sodium.....50 mg
Serratiopeptidase.....15 mg
Paracetamol..........325 mg
        Therapeutic Indications & Usage
        DUOFLAM SP is indicated for:
  • Trauma Surgery: In sports injuries, sprains, laceration, fractures, dislocation and osteoarthritis etc.
  • Surgery: To reduce post-operative edema at injection sites, internal tissue edema and inflammation caused at post-operative handling.
  • Plastic Surgery: For diminishing post-operative edema, restoring micro-circulation at the site of graft and minimizing risk of graft rejection along with reduction in pain.
  • Infections: Facilitating mucolysis in sinuses, ear cavities and coupled with anti-inflammatory activity in upper respiratory tract affections helps in faster resolution, better antimicrobial availability in infected tissues and faster cures.
  • Dermatology: Particularly useful in acutely painful inflamed dermatosis.
  • Dentistry: Helps better control over dental infections and inflammation.
  • Obstetrics & Gynecology: The anti-inflammatory and anti-edema activity helps in resolution of post-partum hematomas, breast engorgements and pregnancy-related thrombophlebitis.
        DUOFLAM SP is contraindicated in those who are hypersensitive to its ingredients.
        Precaution & Warnings
        Diclofenac (in DUOFLAM SP) should be administered with caution in patients with acid-peptic disease, impaired renal or liver functions, blood dyscrasias, and in patients with hypersensitivity to aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs).
        DUOFLAM SP should be used in pregnant women and nursing mothers only if absolutely required Data on safety and efficacy of diclofenac / serratiopeptidase (DUOFLAM SP) in children is not adequate.
        Since serratiopeptidase can enhance the action of anticoagulants, DUOFLAM SP must be coadministered with due precaution.
        Adverse Reactions
        The most common side effects of diclofenac (in DUOFLAM SP) are gastric pain, nausea, vomiting and diarrhea; rarely peptic ulcer and gastrointestinal bleeding occur. Infrequently, hypersensitivity reactions, malaise, change in appetite and weight, and eye disorders are possible due to diclofenac (in DUOFLAM SP). Neurological reactions possible include headache, drowsiness, insomnia, irritability and mood disturbances. Diclofenac (in DUOFLAM SP) can rarely cause hepatitis, renal dysfunction and blood dyscrasias.
        Serratiopeptidase (in DUOFLAM SP) can cause hypersensitivity reactions such as rash or redness, besides gastrointestinal side effects like anorexia, abdominal discomfort, nausea and vomiting
        Drug Interactions
        Concomitant use of diclofenac (in DUOFLAM SP) with aspirin, methotrexate, digoxin, cyclosporin, triamterene and lithium is not advocated due to possibility of drug interaction. If coadministered with anticoagulants, serratiopeptidase (DUOFLAM SP) can increase the anticoagulative action.
        Recommended Dosage & Administration
        Oral Administration
        1 DUOFLAM SP Tablet three times daily 1-2 hours after meals
        DUOFLAM SP Tablets: Blisters of 10s


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