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FLUCOFIT Tab.:

 
         
       
       
           
           
       
         
         
       
        Composition
         
        Each tablet of FLUCOFIT contains;
        Fluconazole……150 mg
         
         
        Therapeutic Indications & Usage
         
        Recurrent vulvovaginal candidiasis
         
         
        Contraindications
         
       
  • Hypersensitivity to fluconazole or any ingredient in the formulations.
  • Concomitant use with drugs that are known to prolong the QT interval and are metabolized by CYP3A4 (e.g., astemizole, cisapride, pimozide, quinidine).
         
        Precaution & Warnings
         
        -
         
        Adverse Reactions
         
        GI effects (nausea, vomiting, abdominal pain, diarrhea), rash, transient increases in liver enzymes and bilirubin
         
         
        Drug interaction
         
        Drugs Metabolized by Hepatic Microsomal Enzymes
         
        Fluconazole is a potent inhibitor of CYP2C9 and a moderate inhibitor of CYP3A4.1 Because fluconazole has a long half-life, the enzyme-inhibiting effects of the drug persist for 4–5 days following discontinuance.1 Concomitant use of fluconazole and drugs metabolized by CYP2C9 or 3A4 may result in increased plasma concentrations of the concomitant drug; use caution and monitor closely.1
         
        Drugs that Prolong the QT Interval
         
        Concomitant use of fluconazole with drugs known to prolong the QT interval and that are metabolized by CYP3A4 is contraindicated
         
         
        Recommended Dosage & Administration
         
        Oral 150 mg FLUCOFIT given for 3 doses to achieve mycologic remission, then maintenance regimen of 150 mg once weekly for 6 months to prevent recurrence.
         
         
        Presentations
         
        FLUCOFIT TAB. – Three separate strips of fluconazole 150mg in a single pack
         
       
         
       
       
         
       
 

 

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