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L 250/500:

 
         
       
       
           
           
       
         
         
       
        Composition
         
        Each tablet of L 250/500 contains:
        Levofloxacin …250 mg/500 mg
         
         
        Therapeutic Indications & Usage
         
       
  • Respiratory Tract Infections
  • Acute Bacterial Sinusitis
  • Acute Exacerbations of Chronic Bronchitis
  • Community-acquired Pneumonia (CAP)
         
        Contraindications
         
        Known hypersensitivity to levofloxacin or other quinolones
         
         
        Precautions & Warnings
         
        Tendinopathy and Tendon Rupture
         
        Fluoroquinolones, including levofloxacin, are associated with increased risk of tendinitis and tendon rupture in all age groups This risk is further increased in older adults (usually those >60 years of age), individuals receiving concomitant corticosteroids, and kidney, heart, or lung transplant recipients. 129 (See Geriatric Use under Cautions.)
         
        Other factors that may independently increase risk of tendon rupture include strenuous physical activity, renal failure, and previous tendon disorders such as rheumatoid arthritis Tendinitis and tendon rupture have been reported in patients receiving fluoroquinolones who did not have any of these risk factors.
         
        Fluoroquinolone-associated tendinitis and tendon rupture most frequently involve the Achilles tendon and may require surgical repair.1 Tendinitis and tendon rupture in the rotator cuff (shoulder), hand, biceps, thumb, and other tendon sites also reported.
         
        Tendon rupture can occur during or following fluoroquinolone therapy and has been reported up to several months after completion of therapy.1
         
        Discontinue if pain, swelling, inflammation, or rupture of a tendon occurs. Advise patients to rest and refrain from exercise and contact a clinician at the first sign of tendinitis or tendon rupture (e.g., pain, swelling, or inflammation of a tendon; weakness or inability to use a joint).
         
         
        Adverse Reactions
         
        GI effects (nausea, diarrhea, constipation); headache; insomnia; dizziness
         
         
        Drug Interaction
         
        Does not inhibit and is not metabolized by CYP isoenzymes.1 Pharmacokinetic interactions with drugs metabolized by CYP isoenzymes unlikely.1
         
         
        Recommended Dosage & Administration
         
        500 mg once every 24 hours for 7 -10 days.
Or as directed by Physician
         
         
        Presentation;
         
        L 250 : Blister of 10 Tabs
L 500 : Blister of 5 Tabs.
         
       
         
       
       
         
       
 

 

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