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DIBACT:

 
         
       
       
           
           
       
         
         
       
        Composition
         
        Each Vial of Dibact 250mg contains:
        Ceftriaxone Sodium USP equivalent to Ceftriaxone 250mg, Tazobactam Sodium Equivalent to Tazobactam 31.25 mg. Supplied with 5ml sterile water for injection I.P.
         
        Each Vial of Dibact 500mg contains:
        Ceftriaxone Sodium USP equivalent to Ceftriaxone 500mg, Tazobactam Sodium Equivalent to Tazobactam 62.5mg. Supplied with 5ml sterile water for injection I.P.
         
        Each Vial of Dibact 500mg contains:
        Ceftriaxone Sodium USP equivalent to Ceftriaxone 1000mg, Tazobactam Sodium Equivalent to Tazobactam 125mg. Supplied with 5ml sterile water for njection I.P.
         
         
        Therapeutic Indications & Usage
         
        Dibact is indicated for meningitis, pneumonia, typhoid, PID, salpingitis, bacterial meningitis & intraabdominal infections like peritonitis, liver abscess.
         
         
        Contraindications
         
        Dibact should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics. Caution in patients with a history of GI disease, especially colitis. Discontinue treatment in patients who develop signs/symptoms suggestive of gallbladder disease.
         
         
        Precautions & Warnings
         
        Its safety in human pregnancy has not been established. Therefore it should not be used in pregnancy unless absolutely indicated. Only minimal amount of Ceftriaxone is excreted in breast milk, so Mother-receiving Ceftriaxone should not breast-feed. In severe renal impairment accompanied by hepatic insufficiency, dosage reduction is required.
         
         
        Adverse Reaction
         
        Superinfection; anaphylaxis; diarrhoea; local reactions; blood dyscrasias; rash, fever, pruritus; elevated transaminases and alkaline phosphatase. GI effects; pseudomembranous colitis; hematologic effects; hypersensitivity reactions; CNS disturbances; hypertension; chest pain; edema; moniliasis; rhinitis; dyspnea; hypotension; ileus; syncope; local Injections site reactions; rigors.
         
        Potentially Fatal: Pseudomembranous colitis; nephrotoxicity
         
         
        Drug interactions
         
        Potentially Fatal: Disulfiram-like reaction with alcohol. Nephrotoxicity with aminoglycosides &       furosemide
         
         
        Recommended Dosage & Administration
         
        Adult
        1000/125 – 2000/250 mg IV & IM, once a day or equally divided as twice daily
For uncomplicated gonococcal infections 250mg once daily.
For surgical prophylaxis 1000-125mg1/2 to 2 before surgery IV & IM single dose
         
        Children
        50/75 mg/kg(in ceftriaxone) IV & IM,every 12 hrs, with max dose is 2 gm in terms of ceftriaxone For meningitis100 mg/kg on 1st day and thereafter 80 mg/kg/day once daily (in terms of ceftriaxone) IV & IM with max dose is 4 gm
         
         
        Presentation
         
        DIBACT injection- vial of 250/500/1g
         
         
       
         
       
       
         
       
 

 

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