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FEBRINIL -IV 100ml:

 
         
       
       
           
           
       
         
         
       
        Composition
         
        For intravenous infusion only
         
        Each 100ml contains Each 100 ml contains: Paracetamol IP 1g,Water for injection IP q.s. Excipients: Propylene glycol IP, PEG 400 USP, Sodium metabisulfite IP, Sodium thiosulfate IP, Sodium acetate anhydrous USP.
         
         
        Therapeutic Indications & Usage :
         
        Febrinil IV 100 ml solution for infusion is indicated for the short-term treatment of moderate pain,especially following surgery, and for the short-term treatment of fever, when administration by intravenous route is clinically justified by an urgent need to treat pain of hyperthermia and/or when other routes of administration are not possible.
         
         
        Contraindications :
         
        Clinical signs and symptoms of liver damage are not usually seen until two days, and up to a maximum of 4-6 days, after administration. Treatment with antidote should be given as soon as possible
         
         
        Precautions for use
         
        The total dose of paracetamol should not exceed 4g per day. If the daily dose of paracetamol from all sources exceeds the maximum, severe hepatic injury may occur.
         
         
        Renal impairment
         
        Paracetamol should be administered with caution to patients with renal impairment. In cases of severe renal impairment (creatinine clearance 10-30 mL/min), the elimination of paracetamol is slightly delayed, the elimination half-life ranging from 2 to 5.3 hours. While giving paracetamol to patients with severe renal impairment(creatinine clearance 30mL/min),the minimum interval between each administration should be increased to 6 hours
         
         
        Hepatic impairment
         
        Paracetamol should be administered with caution to patients with hepatic impairment. Hepatic impairment may decrease the clearance of paracetamol or increase the probability of hepatic toxicity.
         
         
        Pregnancy
         
        Pregnancy category A
Paracetamol IV should only be used during pregnancy after a careful benefit- risk assessment. In this case, the recommended dosage and duration must be strictly observed.
         
         
        Lactation
         
        No undesirable effects on nursing infants have been reported.
         
         
        Adverse Reactions
         
        Side effects of paracetamol (FEBRINIL) are rare, and usually mild. Skin rashes and other hypersensitivity reactions could occur, and, on rare occasions, paracetamol could cause hematological changes.
         
        Drug Interaction
         
        Probenecid can decrease it's clearance whilst cholestyramine diminishes absorption of paracetamol when co administered.
         
         
        DOSAGE AND ADMINISTRATION
         
        Intravenous use
Febrinil IV 100 ml solution for infusion should not be mixed with other medicinal products.
Paracetamol 1 g per administration, i.e. one 100 ml bottle, up to four times a day. The minimum interval between each administration must be 4 hours in patients without hepatic impairment. The maximum daily dose from all sources of paracetamol must not exceed 4 g. The paracetamol solution is administration as a 15 -minute intravenous infusion.
It contains no antimicrobial agent is for single use in one patient only.
Dosage for renal and hepatic failure:
In patients with renal and/or hepatic impairment the minimum interval between doses must not be less than 6 hours.
         
         
        Presentation
         
        Febrinil IV 100ml-bottle of 100ml
         
       
         
       
         
       
 

 

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