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        Each film coated tablet contains: Cefixime IP as Trihydrate equivalent to Anhydrous Cefixime 200 mg, Pottassium Clavulanate Diluted IP equivalent to Clavulanic Acid 125 mg,excipients q.s.
        Therapeutic Indications & Usage:
        SI-FIXIM-CV200 is indicated for the treatment of infections caused by resistant bacteria:
        • Upper respiratory tract infections, such as pharyngitis, sinusitis, otitis media, tonsillitis.
• Lower respiratory tract infections, such as acute bronchitis and acute exacerbation of chronic bronchitis
• Uncomplicated urinary tract infections.
        SI-FIXIM-CV 200 is not advocated for those with a history of hypersensitivity to beta-lactams, e.g:penicillins and cephalosporins.
        Precautions & Warnings:
        Before therapy with SI-FIXIM-CV 200 is instituted, careful inquiry should be made to determine ,whether the patient has had previous hypersensitivity reactions to cephalosporins, penicillins or other drugs.Cefixime as with other broad-spectrum antibiotics should be prescribed with caution in individuals with a history of colitis.Increases in prothrombin times occur & therefore care should be taken in patients receiving anticoagulant therapy.No adequate and well-controlled studies in pregnant women have been reported so SI-FIXIM-CV200 should therefore not be used in pregnancy or in nursing mothers unless considered essential by the physician.
        Adverse Reactions
        The most frequent adverse effect is gastrointestinal (GI) complaints, and diarrhea incidence is 16%.Other side effects include hypersensitivity reactions, liver / renal dysfunction, headaches, dizziness, seizures, hematopoietic changes, genital pruritus, vaginitis, candidiasis.

Drug Interactions.


Carbamazepine: Elevated carbamazepine levels have been reported when cefixime is administered


Warfarin and Anticoagulants: Increased prothrombin time, with or without clinical bleeding, has been reported when cefixime is administered concomitantly.

        Oral Contraceptives: Cefixime may interfere with the effectiveness of birth control pills.
        Glucose Test: A false positive reaction for glucose in the urine may occur with Benedict's or Fehling's solutions or with copper sulphate test tablets.
        Coombs test: A false positive direct Coombs test has been reported during treatment with cephalosporin antibiotics.
        Recommended Dosage & Administration

Adults and Children over 10 Years: One tablet twice daily The usual course of treatment is 7 days.
This may be continued for up to 14 days if required.


Adults: The recommended dose of Sifixim CV is 200 – 400mg daily. This may be given as once daily dose or in two divided doses every 12 hours.

        Children: Usual recommended dose in children for upper and lower respiratory tract infection, otitis media & urinary tract infections is 8mg/kg/day as a single or two divided doses.
        SI-FIXIM-CV200 - Strip of 10 tablets.


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