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SI-FIXIM:

 
         
       
       
           
           
       
         
         
       
        Composition
         
        Each dispersible tablet of SI-FIXIM 50 / 100 DT contains:
Cefixime trihydrate Equivalent to anhydrous cefixime … 50 / 100 mg
Each tablet of SI-FIXIM 200 DT contains: Cefixime trihydrate Equivalent to anhydrous cefixime … 200 mg Each 5 ml of reconstituted SI-FIXIM Dry Syrup contains: Cefixime trihydrate Equivalent to anhydrous cefixime … 50 mg
         
         
        Therapeutic Indications & Usage
         
        SI-FIXIM is indicated for the treatment of infections caused by susceptible bacteria:
• Upper respiratory tract infections, such as pharyngitis, sinusitis, otitis media, tonsillitis.
• Lower respiratory tract infections, such as acute bronchitis and acute exacerbation of chronic bronchitis.
• Uncomplicated urinary tract infections.
• Uncomplicated gonorrhea.
         
         
        Contraindications
         
        SI-FIXIM is not advocated for those with a history of hypersensitivity to beta-lactams, e.g. penicillins and cephalosporins.
         
         
        Precautions & Warnings
         
        SI-FIXIM should be advocated with caution in presence of renal impairment or GI disease, particularly colitis. Prolonged use of SI-FIXIM could result in overgrowth of non-susceptible organisms. If superinfections occur (usually involving Aerobacter, Pseudomonas or Candida spp), SI-FIXIM should be discontinued and/or appropriate therapy instituted.
Periodic assessment of hematopoietic function is advisable during prolonged SI-FIXIM therapy. SI-FIXIM is not ideally meant for pregnant lady or lactating mother; however, it could be only if strictly necessary. Nursing discontinuation temporarily must be considered whilst taking SI-FIXIM. Safety and efficacy of cefixime (SI-FIXIM) in children less than 6 months old have not been established.
SI-FIXIM must be coadministered with carbamazepine, warfarin and other anticoagulants.
         
         
        Adverse Reactions
         
        The most frequent adverse effect is gastrointestinal (GI) complaints, and diarrhea incidence is 16%. Other side effects include hypersensitivity reactions, liver / renal dysfunction, headaches, dizziness, seizures, hematopoietic changes, genital pruritus, vaginitis, candidiasis.
         
         
        Drug Interaction
         
        Elevated carbamazepine levels occur when cefixime (SI-FIXIM) is coadministered. When given with warfarin / anticoagulants, the prothrombin time is elevated. Probenecid can decrease it's clearance, whilst cholestyramine diminishes absorption of paracetamol (in NIMCET Plus) when coadministered.
         
         
        Recommended Dosage & Administration
         
        Adults
Susceptible infections: 1 SI-FIXIM 200 Tab / 2 SI-FIXIM 100 DT bid, or 2 SI-FIXIM Tabs od, or as prescribed.
         
        Uncomplicated cervical / urethral gonococcal infections: 2 SI-FIXIM Tabs , or as prescribed.
         
        Children
<50 kg: 8 mg/kg/day of SI-FIXIM Suspension / SI-FIXIM 50 / 100 DT either as single dose or in two divided doses. >50 kg:
         
         
        Presentation
         
       

SI-FIXIM 50 / 100 DT: Blister strips of 10s.

       

SI-FIXIM 200 DT: Blister strips of 10s.

        SI-FIXIM Dry Syrup: Bottles of 30 ml.
         
       
         
       
         
       
 

 

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